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Alitretinoin treatment should start on the second or third day of the next normal menstrual period following this negative pregnancy test. Heart or blood vessel disease (eg, coronary insufficiency) or Heart rhythm problems (eg, arrhythmia, prolonged QT interval) or Problems passing urine or Thyrotoxicosis (excess thyroid hormone in the body)—Use with caution. Avoid contact with the eyes and other mucous membranes Position the patient supine with the brain (including the cerebellum) within a single field of view.